Overall Success Rate: 85%
Last Updated: February 15, 2017

Official Site:

Background Check

Prevagen is a little different from some of the other brain supplements we’ve reviewed here before: it’s based off just one interesting ingredient – jellyfish! It’s risen to popularity in the few years that it’s been around, garnering a substantial following online. Prevagen is being marketed as supplement to the elderly that’s supposed to protect your brain, while strengthening its neurons and fighting against age-related diseases (note – these are the claims of the manufacturer and in no way should they be taken as fact). There’s a high chance that an elder family member of yours is already taking Prevagen, so it might be a good idea to ask around to see what their personal experiences are.

In its basic form, Prevagen is a natural extract once taken from jellyfish called “Apoaequorin” that was believe to help fight aging. Checking out the website, there are lots of resources available for those of you who’d like to do a little bit more reading on what Prevagen does. We have to be honest that it seems pretty convincing, especially taking into consideration the double blind clinical studies they’re citing on their website, as well as some other supporting research.

When it all comes down to it, the website is very informative and the manufacturers try to do a good job at explaining everything you need to know (after all, we imagine it’s pretty difficult to try and sell someone on the idea that a jellyfish extract is going to do wonders for the brain). However, the video that automatically plays upon landing on the website pretty much sums up what you need to know about it.

Other resources included in the website are the supplement facts label and also what they call “Prevagen games” (mind puzzles).

“We have proteins in our brain that are responsible for keeping the cells alive that control learning
and memory, clear thinking and concentration. These proteins deplete with age. Prevagen is the only
all-natural option to replace these proteins. In scientific studies, Prevagen protects cells by up to 50%. Protect brain cells with Prevagen.”


Formula Highlights

Supplement Facts:
Apoaequorin 10 mg

We weren’t kidding when we said that the formula was based off the jellyfish extract, Apoaequorin. That’s basically the one and only ingredient in the formula.

Apoaequorin is a unique protein extracted from jellyfish that was first discovered by E. Newton Harvey in 1921 in an experiment concerning the bioluminescence of some types of jellyfish. Apoaequorin was originally identified in a rare species of jellyfish called Aequorea victoria. As a protein, Apoaequorin helps the brain and the nervous system do their jobs correctly.

Apparently, production of this protein in the body is high when we were younger, but the production slowly comes to a halt as we age. With the Apoaequorin in Prevagen, you should be able to properly balance the processes that occur inside your brain, allowing you to protect your brain from damage and continually keep it maintained, while allowing it to perform the complex tasks you undertake every day at an optimum level.

There isn’t really a lot we can say about Prevagen’s formula solely because of the fact that there’s just one ingredient, but the studies backing it up are quite convincing, and the clinical studies shown on their website are also a nice touch. Prevagen now synthesizes the Apoaequorin in their lab.

Rating: 15/20

Effects and Benefits

For a supplement that has only one ingredient, Prevagen works quite well! Our experience with Prevagen was like a roller coaster ride – it had its ups and downs, but it was ultimately unlike any other supplement we’ve tested before.

Prevagen didn’t produce any effects for focus or mood. There were no buzzes or highs at all. Instead, Prevagen gave us a sense of general wellbeing. We just felt a lot healthier while on Prevagen, and throughout the whole experience, we generally felt more positive.

Overall, our experience with Prevagen was a little weird, but at the same time quite unique… and definitely an unforgettable one.

Rating: 17/20

 Potential Side Effects

Surprisingly, none of us experienced any side effects while taking Prevagen. Everyone mostly ended their days with a bang, being able to go home with a clear head, and waking up the next day fresh and ready to take on the obstacles of the day. We didn’t run into any complications whatsoever, and perhaps this is due to the fact that there really is only one ingredient in Prevagen. Of course, these were just our experiences, and if you should have a negative interaction, we advise that you stop taking Prevagen for a few days.

Please keep yourself well hydrated while on Prevagen, as dehydration can be caused by some supplements.

Rating: 20/20

Pricing Options

There are a number of different pricing options for Prevagen, beginning at the $59.95 for a 30-count bottle. With a serving size of one capsule a day, the bottle should last you the whole month. There are also 2-packs, 4-packs, and a year’s supply available with small discounts in place.

Prevagen is also offered in double strength (where Apoaequorin available at 20 mg), as well as in chewable tablets for those who have a hard time swallowing pills.

For the price, Prevagen is a little on the expensive side, especially considering that there really is just one ingredient in the formula, and that it isn’t that effective for either focus or mood. There are other nootropic options out there that are priced similarly but offer an overall better package.

Rating: 16/20

Online Reviews

There are a lot of reviews on Prevagen available on their website, but they do limit the negative reviews there. For a more rounded view, check out the reviews on Amazon!

User Review by Tom on

I bought this product for my father, 81 on the recommendation of a friend who is a doctor. After about a week Dad said he didn’t notice a difference. He called me last week to tell me he finished the crossword puzzle in newspaper for the first time in years. He was thrilled! He’s been able to come pretty close to finishing the crossword every day now for the past week or so.

My wife and I started taking it about two weeks ago. One odd thing I noticed is that I dream very vividly and actually remember a lot of what I dream. I didn’t think much of it and didn’t say anything to my wife because I knew she would think I was nuts. This morning she came downstairs and said “you wouldn’t believe my dream last night” and then proceeded to tell me in great detail (more than I wanted to know actually) about her dream.

I have taken ginkgo and other memory enhancing supplements that were all a waste of money. This one is pretty amazing.

User Review by Jason on

Having a degree in biochemistry, it’s my opinion that Prevagen does almost nothing more than the placebo effect. Disregarding the sketchy clinical trials cited, the active ingredient is a protein compound (apo-Aequorin) that gets broken down upon digestion into its component amino acids. While Aequorin certainly does bind calcium, even if it did survive digestion it is unlikely to pass the blood-brain barrier and is more likely to bind calcium in the body first. At best it is a dose of protein and, by the looks of the other ingredients, EDTA, which is known to chelate (i.e., bind) calcium and other metal ions like iron. This could probably pass the blood-brain barrier, however higher doses of EDTA (2 g/kg) are known to be toxic to lab rats and the quantity of EDTA in Prevagen is unreported. If the purported effects of Prevagen work as a placebo for you or your loved one, by all means, continue.

Rating: 17/20



  • Unique formula and ingredient “Apoaequorin”
  • Website is rich in information and resources for further reading
  • Clear video on website that explains Prevagen in simplistic way



  • Little to no effects on focus and mood
  • Poor value at $59.95 (better nootropics available at that price)
  • Studies on Apoaequorin are still quite limited today.

Our Verdict

Let’s get this out of the way: Prevagen is unique. We haven’t seen a formula like this before, especially when it comes to matters of the brain. It’s a bold move for a manufacturer to try to go into a different direction by using some newly discovered “super ingredient”, but fortunately, it works for Prevagen.

Apoaequorin is a promising extract from jellyfish, but unfortunately, there isn’t a lot of research out there about it.

Our tests went well, and were incredibly weird, but also remarkable. Prevagen seemed to have greater effects on our senior editors than our young reviewers. Prevagen is priced averagely when compared to other brain supplements, but we can’t fully recommend it simply because there are other premade nootropic formulas there that give a better all-around experience for the same price.

It might not be the best memory enhancer available out there, but it sure is one of the most interesting ones we’ve ever come across.

Prevagen Reviewed by Top Cognitive Enhancers. Rating:85%
Last Updated: February 10, 2017
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